Rae was known for her portrayal of Edna Garrett in the sitcoms Diff'rent Strokes and its spin-off, The Facts of Life (in which she had the starring role from 1979 to 1986). She received a Primetime Emmy Award nomination for Best Actress in a Comedy in 1982. She also appeared in two Facts of Life television films: The Facts of Life Goes to Paris in 1982 and The Facts of Life Reunion in 2001. She voiced the character of "Nanny" in 101 Dalmatians: The Series and Aunt Pristine Figg in Tom and Jerry: The Movie. She also appeared as Gammy Hart in Girl Meets World.
In 2015, she returned to film in the feature film Ricki and the Flash, with Meryl Streep, Kevin Kline, and Rick Springfield. In November 2015, Rae released her autobiography, The Facts of My Life, which was co-written with her son, Larry Strauss.
